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Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

[ Vol. 19 , Issue. 7 ]

Author(s):

Sukriti Vishwas, Monica Gulati, Bhupinder Kapoor, Saurabh Gupta*, Sachin Kumar Singh*, Ankit Awasthi, Arzoo Khan, Aditya Goyal, Anil Bansal, Suman Baishnab, Thakur Gurjeet Singh, Sandeep Arora, Omji Porwal, Ankit Kumar and Vijay Kumar   Pages 957 - 989 ( 33 )

Abstract:


Huntington’s disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive, and behavioral dysfunctions associated with HD. In addition to this, their chronic use is limited by their long-term side effects. Herbal drugs offer a plausible alternative to this and have shown substantial therapeutic effects against HD. Moreover, their safety profile is better in terms of side effects. However, due to limited drug solubility and permeability to reach the target site, herbal drugs have not been able to reach the stage of clinical exploration. In recent years, the paradigm of research has been shifted towards the development of herbal drugs based nanoformulations that can enhance their bioavailability and blood-brain barrier permeability. The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers, along with their potential neuroprotective effects.

Keywords:

Huntington's disorder, oxidative stress, herbal medicine, neuroprotective effects, blood-brain barrier, nanocarriers.

Affiliation:

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Chitkara College of Pharmacy, Chitkara University, Punjab-140401, Department of Pharmacognosy, Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411, Department of Biotechnology, School of Bioengineering and Biosciences, Faculty of Technology and Sciences, Lovely Professional University, Phagwara-144411, Punjab

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