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Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

[ Vol. 19 , Issue. 5 ]

Author(s):

Lingdi Nie, Wen-Rui Ye, Shangbin Chen, Domenico Chirchiglia and Minyan Wang*   Pages 665 - 678 ( 14 )

Abstract:


Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.

Keywords:

Src family kinase, NMDA receptors, P2X receptors, neuroinflammation, migraine, neuropathic pain.

Affiliation:

Department of Biological Sciences, Centre for Neuroscience, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, 215123, Department of Biological Sciences, Centre for Neuroscience, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, 215123, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics- Huazhong University of Science and Technology, Wuhan, 430074, Department of Medical and Surgical Science, School of Medicine, University of Catanzaro, Catanzaro, Department of Biological Sciences, Centre for Neuroscience, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, 215123

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