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Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease

[ Vol. 19 , Issue. 7 ]

Author(s):

Fabiana Labanca, Hammad Ullah, Haroon Khan*, Luigi Milella, Jianbo Xiao, Zora Dajic-Stevanovic and Philippe Jeandet   Pages 1007 - 1018 ( 12 )

Abstract:


Curcumin is a spice derived nutraceutical which gained tremendous attention because of its profound medicinal values. It alters a number of molecular pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF‐κB), signal transducer and activator of transcription 3 (STAT3), nuclear factor erythroid 2-related factor 2 (Nrf2) and cyclooxygenases-2 (COX‐2), which make it potential therapeutic choice in treating multiple disorders. It also possesses the potential to prevent protein aggregation and thus protect against degeneration of neurons in neurodegenerative disorders including Huntington’s disease (HD). HD is an autosomal dominant disorder linked with altered gene expression which leads to an increase in the size of cytosine, adenine and guanine (CAG) trinucleotide repeats, aids in protein aggregation throughout the brain and thus damages neurons. Upstream regulation of oxidative stress and inflammatory cascade are two important factors that drive HD progression. Available therapies just suppress the severity of symptoms with a number of side effects. Curcumin targets multiple mechanisms in treating or preventing HD including antioxidant and anti-inflammatory potential, metal ion chelation, transcriptional alterations and upregulating activity of molecular chaperons, heat shock proteins (HSPs). Having a favorable safety profile, curcumin can be an alternative therapeutic choice in treating neurodegenerative disorders like HD. This review will focus on mechanistic aspects of curcumin in treating or preventing HD and its potential to arrest disease progression and will open new dimensions for safe and effective therapeutic agents in diminishing HD.

Keywords:

Curcumin, huntington's disease, therapeutic potential, degenerative diseases, oxidative stress, neuroinflammation, underlying mechanisms.

Affiliation:

Dipartimento di Scienze, Universitadella Basilicata, Viadell’Ateneo Lucano, 10 85100 Potenza (PZ), Department of Pharmacy, University of Naples Federico II, Naples, Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Dipartimento di Scienze, Universitadella Basilicata, Viadell’Ateneo Lucano, 10 85100 Potenza (PZ), International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, University of Belgrade, Faculty of Agriculture, Serbia Nemanjina 6, 11080 Belgrade, Induced Resistance and Plant Bioprotection, Faculty of Sciences University of Reims Champagne-Ardenne, Reims Cedex 51687

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