Submit Manuscript  

Article Details

Effects of Mulberry on The Central Nervous System: A Literature Review

[ Vol. 19 , Issue. 2 ]


Dao Ngoc Hien Tam, Nguyen Hai Nam, Mohamed Tamer Elhady, Linh Tran, Osama Gamal Hassan, Mohamed Sadik, Phan Thi My Tien, Ghada Amr Elshafei and Nguyen Tien Huy*   Pages 193 - 219 ( 27 )


Background: Mulberry, including several species belonging to genus Morus, has been widely used as a traditional medicine for a long time. Extracts and active components of mulberry have many positive neurological and biological effects and can become potential candidates in the search for new drugs for neurological disorders.

Objectives: We aimed to systematically review the medical literature for evidence of mulberry effects on the central nervous system.

Methods: We conducted a systematic search in nine databases. We included all in vivo studies investigating the effect of mulberry on the central nervous system with no restrictions.

Results: We finally included 47 articles for quality synthesis. Our findings showed that mulberry and its components possessed an antioxidant effect, showed a reduction in the cerebral infarct volume after stroke. They also improved the cognitive function, learning process, and reduced memory impairment in many animal models. M. alba and its extracts ameliorated Parkinson's disease-like behaviors, limited the complications of diabetes mellitus on the central nervous system, possessed anti-convulsant, anti-depressive, and anxiolytic effects.

Conclusion: Mulberry species proved beneficial to many neurological functions in animal models. The active ingredients of each species, especially M. alba, should be deeper studied for screening potential candidates for future treatments.


Mulberry, Morus, neurology, systematic review, memory improvement, antidepression.


Asia Shine Trading & Service Co. LTD., Ho Chi Minh City, Department of General Surgery, University of Medicine and Pharmacy at Ho Chi Minh City, Pediatric Department, Zagazig University Hospital, Sharkia, Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City 700000, Faculty of Medicine, South Valley University, Qena, Faculty of Pharmacy, Al-Azhar University, Cairo, University of Medicine and Pharmacy at Ho Chi Minh City, Faculty of Medicine, Cairo University, Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, 700000

Graphical Abstract:

Read Full-Text article