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Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response

[ Vol. 18 , Issue. 4 ]

Author(s):

Pierre Mesdom, Romain Colle, Elise Lebigot, Séverine Trabado, Eric Deflesselle, Bruno Fève, Laurent Becquemont, Emmanuelle Corruble and Céline Verstuyft*   Pages 301 - 318 ( 18 )

Abstract:


Background: Human dermal fibroblasts (HDF) can be used as a cellular model relatively easily and without genetic engineering. Therefore, HDF represent an interesting tool to study several human diseases including psychiatric disorders. Despite major depressive disorder (MDD) being the second cause of disability in the world, the efficacy of antidepressant drug (AD) treatment is not sufficient and the underlying mechanisms of MDD and the mechanisms of action of AD are poorly understood.

Objective: The aim of this review is to highlight the potential of HDF in the study of cellular mechanisms involved in MDD pathophysiology and in the action of AD response.

Methods: The first part is a systematic review following PRISMA guidelines on the use of HDF in MDD research. The second part reports the mechanisms and molecules both present in HDF and relevant regarding MDD pathophysiology and AD mechanisms of action.

Results: HDFs from MDD patients have been investigated in a relatively small number of works and most of them focused on the adrenergic pathway and metabolism-related gene expression as compared to HDF from healthy controls. The second part listed an important number of papers demonstrating the presence of many molecular processes in HDF, involved in MDD and AD mechanisms of action.

Conclusion: The imbalance in the number of papers between the two parts highlights the great and still underused potential of HDF, which stands out as a very promising tool in our understanding of MDD and AD mechanisms of action.

Keywords:

Human dermal fibroblasts, human skin fibroblasts, major depression, major depressive episode, antidepressant drug, cellular model.

Affiliation:

Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre, Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre, Service de Biochimie Pharmaco-Toxicologie, APHP, Hopitaux Universitaires Paris-Sud, Hopital de Bicetre, Le Kremlin Bicêtre, F-94275, Universite Paris Saclay, Faculte de Medecine Paris Saclay, Le Kremlin Bicetre, F-94276, Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre, Sorbonne University-Saint-Antoine Research Center, UMR-S938, Hospitalo-Universitary Institute of Cardiometabolism ICAN, Department of Endocrinology, Sant-Antoine Hospital, APHP, F-75012, Paris, Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre, Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre, Universite Paris-Saclay, UVSQ, Inserm, CESP, Team MOODS, 94270, Le Kremlin-Bicetre

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