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The Endocannabinoid System May Modulate Sleep Disorders in Aging

[ Vol. 18 , Issue. 2 ]


Eric Murillo-Rodríguez*, Henning Budde, André Barciela Veras, Nuno Barbosa Rocha, Diogo Telles-Correia, Diogo Monteiro, Luis Cid, Tetsuya Yamamoto, Sérgio Machado and Pablo Torterolo   Pages 97 - 108 ( 12 )


Aging is an inevitable process that involves changes across life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have demonstrated that aging will increase its worldwide rate in the coming years. The research on chronic diseases of the elderly is important to gain insights into this growing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies have included the endocannabinoid system as an effective tool since this biological system shows beneficial effects in preclinical models. However, and despite these advances, little has been addressed in the arena of the endocannabinoid system as an option for treating sleep disorders in aging since experimental evidence suggests that some elements of the endocannabinoid system modulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely perspective of the implication of the endocannabinoid system in the regulation of sleep problems reported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid system as therapeutic tools in aging is either inconclusive or still missing.


Cannabidiol, childhood, pharmacology, sleep, rapid eye movement sleep, Aging.


Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan, Faculty of Human Sciences, Medical School Hamburg, Hamburg, Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, School of Health, Polytechnic Institute of Porto, Porto, University of Lisbon, Faculty of Medicine, Lisbon, Sport Science School of Rio Maior-Polytechnic Institute of Santarem, Rio Maior, Sport Science School of Rio Maior-Polytechnic Institute of Santarem, Rio Maior, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Laboratory of Physical Activity Neuroscience, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University, Niteroi, Laboratorio de Neurobiologia del Sueno, Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo

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