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Neuro-toxic and Reproductive Effects of BPA

[ Vol. 17 , Issue. 12 ]

Author(s):

Antonietta Santoro, Rosanna Chianese, Jacopo Troisi, Sean Richards, Stefania Lucia Nori, Silvia Fasano, Maurizio Guida, Elizabeth Plunk, Andrea Viggiano, Riccardo Pierantoni and Rosaria Meccariello*   Pages 1109 - 1132 ( 24 )

Abstract:


Background: Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. It has recognized activity as an endocrine-disrupting chemical and has suspected roles as a neurological and reproductive toxicant. It interferes in steroid signaling, induces oxidative stress, and affects gene expression epigenetically. Gestational, perinatal and neonatal exposures to BPA affect developmental processes, including brain development and gametogenesis, with consequences on brain functions, behavior, and fertility.

Methods: This review critically analyzes recent findings on the neuro-toxic and reproductive effects of BPA (and its analogues), with focus on neuronal differentiation, synaptic plasticity, glia and microglia activity, cognitive functions, and the central and local control of reproduction.

Results: BPA has potential human health hazard associated with gestational, peri- and neonatal exposure. Beginning with BPA’s disposition, this review summarizes recent findings on the neurotoxicity of BPA and its analogues, on neuronal differentiation, synaptic plasticity, neuroinflammation, neuro-degeneration, and impairment of cognitive abilities. Furthermore, it reports the recent findings on the activity of BPA along the HPG axis, effects on the hypothalamic Gonadotropin Releasing Hormone (GnRH), and the associated effects on reproduction in both sexes and successful pregnancy.

Conclusion: BPA and its analogues impair neuronal activity, HPG axis function, reproduction, and fertility. Contrasting results have emerged in animal models and human. Thus, further studies are needed to better define their safety levels. This review offers new insights on these issues with the aim to find the “fil rouge”, if any, that characterize BPA’s mechanism of action with outcomes on neuronal function and reproduction.

Keywords:

BPA, neuronal differentiation, synaptic plasticity, neuroinflammation, epigenetics, hypothalamus, HPG axis, GnRH, Kiss1, reproduction.

Affiliation:

Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Caserta, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, University of Tennessee College of Medicine, Department of Obstetrics and Gynecology, Chattanooga, TN, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Caserta, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, University of Tennessee College of Medicine, Department of Obstetrics and Gynecology, Chattanooga, TN, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Caserta, Department of Movement Sciences and Wellbeing, Parthenope University of Naples, Naples

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