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Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

[ Vol. 17 , Issue. 3 ]

Author(s):

Muneeb U. Rehman, Adil Farooq Wali, Anas Ahmad, Sheeba Shakeel, Saiema Rasool, Rayeesa Ali, Shazada Mudasir Rashid, Hassan Madkhali, Majid Ahmad Ganaie and Rehan Khan*   Pages 247 - 267 ( 21 )

Abstract:


Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. In vitro and in vivo studies have further established the usefulness of natural products in various preclinical models of neurodegenerative disorders. Natural products include phytoconstituents, like polyphenolic antioxidants, found in herbs, fruits, nuts, vegetables and also in marine and freshwater flora. These phytoconstituents may potentially suppress neurodegeneration and improve memory as well as cognitive functions of the brain. Also, they are known to play a pivotal role in the prevention and cure of different neurodegenerative diseases, such as Alzheimer’s disease, epilepsy, Parkinson’s disease and other neuronal disorders. The large-scale neuro-pharmacological activities of natural products have been documented due to the result of either the inhibition of inflammatory processes, or the up-regulation of various cell survival proteins or a combination of both. Due to the scarcity of human studies on neuroprotective effects of natural products, this review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.

Keywords:

Neurological disorders, neuroprotection, plant products, nutraceuticals, natural compounds, chronic neurodegenerative diseases.

Affiliation:

Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Alustang, Srinagar, 190006 J&K, RAKCOPS, RAK Medical & Health Sciences University, Ras AL Khaimah 11172, Department of Nano-Therapeutics, Institute of Nano Science & Technology, Habitat Centre, Phase X, Mohali-160062, Punjab, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006 J&K, Forest Biotech Lab, Department of Forest Management, Faculty of Forestry, University Putra Malaysia, Serdang, Selangor, Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e- Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Alustang, Srinagar, 190006 J&K, Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Alustang, Srinagar, 190006 J&K, Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University Al-Kharj 11942, Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University Al-Kharj 11942, Department of Nano-Therapeutics, Institute of Nano Science & Technology, Habitat Centre, Phase X, Mohali-160062, Punjab

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