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Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance

[ Vol. 17 , Issue. 2 ]

Author(s):

Yağmur Çetin Taş, İhsan Solaroğlu and Yasemin Gürsoy-Özdemir*   Pages 151 - 164 ( 14 )

Abstract:


Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.

Keywords:

Spreading Depression, Peri-infarct depolarization, Stroke, Subarachnoid hemorrhage, traumatic brain injury, migraine.

Affiliation:

Graduate School of Health Sciences, Neuroscience Research Laboratory, University, Istanbul, Research Center for Translational Medicine, Koc University, Istanbul, Graduate School of Health Sciences, Neuroscience Research Laboratory, University, Istanbul

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