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Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System

[ Vol. 16 , Issue. 2 ]

Author(s):

Jose Luis Cortes-Altamirano, Adriana Olmos-Hernandez, Herlinda Bonilla Jaime, Paul Carrillo-Mora, Cindy Bandala, Samuel Reyes-Long and Alfonso Alfaro-Rodríguez*   Pages 210 - 221 ( 12 )

Abstract:


Background: The aim of this review was to identify the mechanisms by which serotonin receptors involved at the central level are able to modulate the nociceptive response. Pain is a defense mechanism of the body that entails physiological, anatomical, neurochemical, and psychological changes, and is defined as an unpleasant sensory and emotional experience with potential risk of tissue damage, comprising the leading cause of appointments with Physicians worldwide. Treatment for this symptom has generated several neuropharmacological lines of research, due to the different types of pain and the various drugs employed to treat this condition. Serotonin [5- HydroxyTryptamine (5-HT)] is a neurotransmitter with seven families (5-HT1–5-HT7) and approximately 15 receptor subtypes. Serotonin modulates neuronal activity; however, this neurotransmitter is related with a number of physiological processes, such as cardiovascular function, gastric motility, renal function, etc. On the other hand, several researches reported that serotonin modulates nociceptive response through 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the Central Nervous System (CNS).

Method: In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation Index for studies evaluating the effects of 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS on the modulation of different types of pain.

Conclusion We concluded that 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS modulate the pain, but this depends on the distribution of the receptors, dose of agonists or antagonists, administration route, pain type and duration in order to inhibit, excite, or even maintain the nociceptive response.

Keywords:

Pain, 5-HT1, 5-HT2, 5-HT3, 5-HT7, central nervous system.

Affiliation:

PhD Program in Biological and Health Sciences, Universidad Autonoma Metropolitana Iztapalapa-Xochimilco- Cuajimalpa, Mexico, Calzada del Hueso 1100, Col. Villa Quietud, Mexico, D.F. 04960, Departament of Neurosciences, Instituto Nacional de Rehabilitacion, “Luis Guillermo Ibarra Ibarra”, Secretaria de Salud, Col. Arenal de Guadalupe, Mexico, D.F. 14389, Departament of Reproductive Biology, Universidad Autonoma Metropolitana Campus Iztapalapa, Mexico, D.F. 09340, Departament of Neurosciences, Instituto Nacional de Rehabilitacion, “Luis Guillermo Ibarra Ibarra”, Secretaria de Salud, Col. Arenal de Guadalupe, Mexico, D.F. 14389, Departament of Neurosciences, Instituto Nacional de Rehabilitacion, “Luis Guillermo Ibarra Ibarra”, Secretaria de Salud, Col. Arenal de Guadalupe, Mexico, D.F. 14389, Departament of Neurosciences, Instituto Nacional de Rehabilitacion, “Luis Guillermo Ibarra Ibarra”, Secretaria de Salud, Col. Arenal de Guadalupe, Mexico, D.F. 14389, Departament of Neurosciences, Instituto Nacional de Rehabilitacion, “Luis Guillermo Ibarra Ibarra”, Secretaria de Salud, Col. Arenal de Guadalupe, Mexico, D.F. 14389

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