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Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder

[ Vol. 16 , Issue. 5 ]

Author(s):

Jairo Vinicius Pinto, Ives Cavalcante Passos, Diego Librenza-Garcia, Grasiela Marcon, Maiko Abel Schneider, Joao Henrique Conte, Joao Pedro Abreu da Silva, Luiza Pereira Lima, Andre Quincozes-Santos, Marcia Kauer-Sant`Anna and Flavio Kapczinski*   Pages 519 - 532 ( 14 )

Abstract:


Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder.

Keywords:

Bipolar disorder, mania, neuron, glia, microglia, astrocyte, oligodendrocyte, brain-blood barrier.

Affiliation:

Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS) (UFRGS), Porto Alegre (RS), Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre (RS), Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON

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