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5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy

[ Vol. 16 , Issue. 1 ]

Author(s):

Hongyan Zhao, Yang Lin*, Shurui Chen, Xin Li* and Hongliang Huo*   Pages 29 - 36 ( 8 )

Abstract:


Background: Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.

Methods: Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: “5-HT3” and “epilepsy”.

Results: An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.

Conclusion: In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.

Keywords:

5-HT3 receptor, epilepsy, antagonists, Neuron, GABA, NMDA.

Affiliation:

Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, Jinzhou Medical University, Jinzhou 121000, Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, School of Life Science Northeast Normal University, Changchun, Jilin 130024

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